Centriselect – A novel approach for centrifugal cell separation

Abstract The separation of bio-suspensions, such as blood, is great interest for many biomedical applications, the extraction leucocytes from whole laboratory analysis specific cells or a mixed cell suspensions bioreactors preparation cellular products cellbased therapy. In particular, mechanical processes have been established rapid biosuspensions. principle based on density particles particle size. Thus, corresponding are centrifugation and/or filtration. standard process to prepare blood donations contains several steps. First separated into different phases by and then further filters containing filtration layers. shortcomings this low yield due bio-particles remaining in filter high costs equipment use multiple devices Here we present proof an adaptive, size-selective that addresses above mentioned shortcomings. designed combine within one step. Therefore novel device was can be used tube. During centrifugation, centrifugal force changes coefficient filter. This separate sized at speeds. Moreover, were hold back removed afterwards increasing speed. way, created gradually release size yielding purity fractions.